Testagen (KEDG) is studied in vitro as a testis-directed short-peptide probe. It is proposed to act at the chromatin/transcriptional level to modulate expression of genes associated with testicular (Leydig/Sertoli) cell function in experimental systems.
It is used as a tool to examine peptide-driven regulation of proliferation and steroidogenesis-associated gene expression in organotypic cultures and rodent models, and as a comparator in tissue-specificity panels. Observed effects depend on concentration, model system and exposure conditions; no physiological outcome is implied.
Applications in Research
- In-vitro study of testicular cell gene-expression and proliferation markers
- Tissue-specificity comparison across related short peptides
- Materials-science note: KEDG has also been characterised as a copper corrosion inhibitor in saline environments
Specifications Summary
| Parameter |
Typical Value / Range |
| Purity (HPLC) |
≥ 99% |
| Appearance |
White to off-white lyophilised powder |
| Molecular Weight |
447.44 g/mol |
| Peptide Type |
Synthetic tetrapeptide |
| Solubility |
Water, buffered aqueous solutions |
| Storage |
–20 °C, desiccated, dark |
| Pack Size |
20 mg (total) |
Precautions & Notes
- Experimental behaviour is dependent on concentration, model system and exposure conditions
- Appropriate experimental controls are recommended
- Prolonged exposure to light, elevated temperature or aqueous environments may reduce stability
- Intended strictly for laboratory research use; not for human or veterinary application
References
Khavinson VKh, Popovich IG, et al. Peptide Regulation of Gene Expression: A Systematic Review. Molecules. 2021;26(22):7053.
https://www.mdpi.com/1420-3049/26/22/7053
The inhibitory effect and adsorption properties of Testagen peptide on copper surfaces in saline environments. Molecules 2024. (PMC12348504)
https://pmc.ncbi.nlm.nih.gov/articles/PMC12348504/
Keywords: Testagen, KEDG, short peptide, synthetic tetrapeptide
