TB-500 is a synthetic N-acetylated seven-residue peptide (Ac-LKKTETQ) corresponding to residues 17-23 of thymosin beta-4, the region containing its actin-binding motif (LKKTET). It is used for experimental investigation of actin-binding dynamics, cell migration and cytoskeletal organisation in controlled research settings.
In biochemical and cellular research models, thymosin beta-4–related peptides are studied for their interaction with G-actin, influencing actin polymerisation and cytoskeletal remodelling. Observed responses depend on peptide concentration, exposure duration, cell type, and experimental conditions.
Applications in Research
• Investigation of actin dynamics and cytoskeletal regulation
• In vitro studies of cell migration and cellular organisation
• Experimental models examining tissue structure and repair signalling
• Reference peptide in thymosin beta-4–related research
Precautions & Notes
- Experimental outcomes depend on cell type and assay conditions.
- Buffer composition, pH, and ionic strength may influence peptide stability.
- Appropriate controls are recommended.
- Intended strictly for laboratory research use only.
References
Sosne G., Qiu P., Goldstein A.L., Wheater M. Biological activities of thymosin beta-4 defined by active sites in short peptide sequences. FASEB Journal, 2010; 24(7):2144-2151.
https://doi.org/10.1096/fj.09-142307
Keywords: TB-500, TB-500 Fragment, Ac-LKKTETQ, Thymosin Beta-4 (17-23), Synthetic Peptide, Actin Regulation, Cytoskeletal Dynamics, Research Peptide
