Ovagen (EDL) is studied in vitro as a short tissue-specific peptide probe for hepatic and gastrointestinal epithelial signalling. In experimental models it is proposed to enter cells and act at the chromatin/transcriptional level, modulating expression of genes associated with hepatocyte proliferation and epithelial homeostasis.
EDL serves as a reference compound for testing tissue-selective effects on proliferation/apoptosis markers (e.g. Ki-67, p53) in cultured tissue. It is a molecular probe; observed effects depend on concentration, model system and exposure conditions.
Applications in Research
- In-vitro study of hepatocyte / GI-epithelial gene-expression regulation in organotypic cultures
- Comparative tissue-specificity screening across related short peptides
- Reference probe for short-peptide chromatin / transcription studies
Specifications Summary
| Parameter |
Typical Value / Range |
| Purity (HPLC) |
≥ 99% |
| Appearance |
White to off-white lyophilised powder |
| Molecular Weight |
375.38 g/mol |
| Peptide Type |
Synthetic linear tripeptide |
| Solubility |
Water, buffered aqueous solutions |
| Storage |
–20 °C, desiccated, dark |
| Pack Size |
20 mg (total) |
Precautions & Notes
- Experimental behaviour is dependent on concentration, model system and exposure conditions
- Appropriate experimental controls are recommended
- Prolonged exposure to light, elevated temperature or aqueous environments may reduce stability
- Intended strictly for laboratory research use; not for human or veterinary application
References
Khavinson VKh, Popovich IG, et al. Peptide Regulation of Gene Expression: A Systematic Review. Molecules. 2021;26(22):7053.
https://www.mdpi.com/1420-3049/26/22/7053
PubChem Compound Summary, CID 444128 (Glu-Asp-Leu).
https://pubchem.ncbi.nlm.nih.gov/compound/444128
Keywords: Ovagen, EDL, synthetic tripeptide
