Synonyms / Designations: Adamax, Adamantyl Acetyl Hexapeptide, Adamantane-modified acetyl hexapeptide
CAS Number:153931-84-9
Molecular Formula: C50H69N11O11S
Molecular Weight: 1032.24 g/mol
Peptide Classification:
Synthetic hexapeptide with adamantane lipid modification
Purity: Designed to specification (HPLC-characterised, typical)
Appearance: White to off-white powder
Pack Size: 5 mg (total)
Storage: Desiccated, protected from light, stored at –20
Solubility: Soluble in DMSO and compatible aqueous buffers depending on formulation
Description & Research Context
ADAMAX is a synthetic hexapeptide incorporating an adamantane moiety, developed for experimental investigation of peptide stability, membrane interaction, and peptide–receptor or peptide–protein interaction dynamics in in vitro research systems. The adamantyl modification is used as a structural tool to enhance lipophilicity and alter physicochemical behaviour relative to non-modified peptide analogues.
In laboratory research settings, ADAMAX is utilised as a model compound for studying peptide modification strategies, formulation behaviour, and structure–function relationships in short bioactive peptides. Observed molecular effects are dependent on experimental design, concentration, and model system and are not indicative of defined biological or clinical outcomes.
Applications in Research
• Investigation of peptide modification and stability strategies
• In vitro studies of short peptide structure–function relationships
• Evaluation of lipid-modified peptide behaviour in formulation systems
• Use as a reference compound in cosmetic or biochemical peptide research
Handling, Reconstitution & Stability
• Handle under dry conditions; peptide is hygroscopic
• Reconstitute in DMSO or suitable buffered aqueous system depending on assay design
• Avoid vigorous agitation during dissolution
• Aliquot reconstituted solutions to minimise freeze–thaw cycles
• Store reconstituted solutions at –20 °C or lower for long-term stability
Specifications Summary
Batch tested Purity: ≥ 99 % (HPLC / SEC, typical)
Appearance: White to off-white powder
Peptide Type: Adamantane-modified synthetic hexapeptide
Molecular Weight: 1032.24 g/mol
Solubility: DMSO; buffered aqueous systems (formulation-dependent)
Storage: –20 °C, desiccated, protected from light
Pack Size: 5 mg
Precautions & Notes
• Experimental behaviour may vary depending on solvent system and formulation
• Lipid-modified peptides may exhibit altered aggregation or binding properties
• Appropriate controls are recommended in all experimental designs
• Intended strictly for laboratory research use only
• Not for human or veterinary application
References
Štimac A. et al. Adamantane in drug delivery systems and surface recognition. Molecules, 2017.
https://www.mdpi.com/1420-3049/22/2/297
Wanka L. et al. The lipophilic bullet hits the targets: medicinal chemistry of adamantane derivatives. Chemical Reviews, 2013.
https://pubmed.ncbi.nlm.nih.gov/23721347/
Pramod M. et al. Adamantylglycine as a high-affinity peptide label for cucurbit[7]uril. Chemical Communications, 2024.
https://pubs.rsc.org/en/content/articlehtml/2024/cc/d4cc00602j
He B. et al. Role of peptide–cell surface interactions in cosmetic peptide applications. Cosmetics, 2023.
https://pubmed.ncbi.nlm.nih.gov/38027006/
Keywords: ADAMAX, Adamantyl Acetyl Hexapeptide, Adamantane Peptide, Synthetic Cosmetic Peptide, Research Peptide
