Synonyms / Designations: Cagrilintide, AM833, Long-acting amylin analogue, Dual amylin receptor agonist
CAS Number:1415456-99-3
Molecular Formula: C194H312N54O59S2
Molecular Weight: 4409.01 g/mol
Peptide Classification: Synthetic long-acting amylin analogue
Purity: ≥ 99 % (HPLC, typical)
Appearance: White to off-white lyophilised powder
Pack Size: Research pack size (varies)
Storage: Desiccated, protected from light, stored at –20 °C
Solubility: Soluble in sterile water and buffered aqueous solutions
Description & Mechanism
Cagrilintide is a synthetic long-acting analogue of the endogenous peptide hormone amylin, developed for experimental investigation of amylin receptor signalling and metabolic regulation. Structural modifications to the native amylin sequence enhance stability and prolong systemic persistence in research models.
In biochemical and cellular research systems, cagrilintide interacts with amylin receptors formed by calcitonin receptor complexes, activating downstream signalling pathways involved in appetite regulation, gastric emptying, and metabolic homeostasis. Experimental studies focus on receptor binding characteristics, signal transduction dynamics, and pathway modulation under controlled conditions. Observed molecular responses are dependent on experimental design, concentration, and model system, and are used to investigate peptide-mediated signalling rather than defined biological or clinical outcomes.
Applications in Research
- As a molecular probe for studying amylin receptor binding and activation
- Investigation of appetite-regulating and metabolic signalling pathways
- In vitro studies examining peptide stability and receptor selectivity
- Use as a reference compound in metabolic and peptide signalling research
Handling, Reconstitution & Stability
- Weigh under dry conditions; peptide is hygroscopic
- Reconstitute in sterile water or appropriate buffered aqueous solution depending on assay requirements
- Avoid vigorous agitation during dissolution
- Filter sterilize if required (e.g. 0.22 µm) immediately prior to use
- Aliquot and store reconstituted solutions at –20 °C (or lower) to minimise degradation
- Avoid repeated freeze–thaw cycles
Specifications Summary
Purity (HPLC): ≥ 99 %
Appearance: White to off-white lyophilised powder
Peptide Type: Synthetic amylin analogue
Solubility: Water, buffered aqueous solutions
Storage: –20 °C, desiccated, dark
Precautions & Notes
- Experimental behaviour of cagrilintide is influenced by receptor expression, concentration, and exposure duration
- Amylin analogues may exhibit signalling profiles distinct from native amylin
- Buffer composition, pH, and ionic strength may affect peptide stability and assay performance
- Appropriate controls are recommended to distinguish specific from non-specific effects
- Intended strictly for laboratory research use; not for human or veterinary application
References
Larsen P.J. et al. Amylin receptor agonism and metabolic regulation. Diabetologia. PubMed abstract and citation:
https://pubmed.ncbi.nlm.nih.gov/36242844/
Gydesen S. et al. Cagrilintide, a long-acting amylin analogue: pharmacology and receptor activity. Diabetes, Obesity and Metabolism. PubMed abstract and citation:
https://pubmed.ncbi.nlm.nih.gov/33502015/
Hay D.L., Poyner D.R. Amylin and calcitonin receptor signalling mechanisms. British Journal of Pharmacology. PubMed abstract and review article:
https://pubmed.ncbi.nlm.nih.gov/18466316/
Novo Nordisk. Scientific communications and research information on AM833 (cagrilintide). Novo Nordisk Science Hub:
https://sciencehub.novonordisk.com/search?query=cagrilintide
Keywords: Cagrilintide, AM833, Amylin Analogue, Metabolic Peptide, Research Peptide
