Thymosin Alpha-1 is a synthetic 28-amino-acid peptide corresponding to an active fragment of the endogenous thymic hormone prothymosin-α. It is widely used in experimental research to investigate immune system regulation, peptide–receptor interactions, and intracellular signalling pathways involved in innate and adaptive immunity.
In biochemical and cellular research systems, Thymosin Alpha-1 has been shown to modulate immune-related signalling pathways, including those associated with antigen presentation, cytokine expression, and T-cell differentiation. Experimental studies commonly examine its influence on toll-like receptor signalling, NF-κB activation, and interferon-related pathways. Observed molecular responses are dependent on concentration, exposure duration, and experimental model.
Applications in Research
- As a molecular probe for studying immune modulation and thymic peptide signalling.
- Investigation of innate and adaptive immune pathway regulation in cellular models.
- In vitro studies examining cytokine signalling, antigen presentation, and T-cell activation.
- Use as a reference peptide in immunology, inflammation, and host-defence research.
Specifications Summary
Purity (HPLC): ≥ 99%
Appearance: White to off-white lyophilised powder
Molecular Weight: ~3108.32 g/mol
Peptide Type: Synthetic thymic peptide analogue
Solubility: Water, buffered aqueous solutions
Storage: –20 °C, desiccated, protected from light
Pack Size: 10 mg
Precautions & Notes
- Experimental behaviour is influenced by immune cell type, receptor expression, concentration, and exposure duration.
- Buffer composition, pH, and ionic strength may affect peptide stability.
- Appropriate controls are recommended.
- Intended strictly for laboratory research use.
References
Romani L. et al. Thymosin alpha 1 activates dendritic cells for antifungal Th1 resistance through toll-like receptor signaling. Blood, 2004.
https://pubmed.ncbi.nlm.nih.gov/14982877/
Keywords: Thymosin Alpha-1, Tα1, Immunomodulatory Peptide, Synthetic Thymic Peptide
