PNC-27 is a synthetic peptide derived from the HDM-2–binding domain of the p53 protein, conjugated to a membrane-penetrating leader sequence. It was developed as a structurally defined research tool to investigate peptide–membrane interactions and p53-associated signalling mechanisms.
In biochemical and cellular research models, PNC-27 has been shown to interact with membrane-associated HDM-2 in certain cell lines, leading to membrane pore formation. Experimental studies focus on peptide–membrane interactions and downstream signalling effects under controlled conditions. Observed effects depend on experimental design, concentration, and model system.
Applications in Research
• Investigation of p53-related signalling mechanisms
• Studies of peptide-induced membrane disruption
• In vitro cytotoxicity and membrane interaction assays
• Use as a reference compound in peptide-based membrane-disruption research
Specifications Summary
Purity: ≥ 99%
Appearance: White to off-white lyophilised powder
Peptide Type: Synthetic p53-derived peptide
Molecular Weight: 4031.72 g/mol
Solubility: Water, buffered aqueous solutions
Storage: –20 °C, desiccated, protected from light
Pack Size: 30 mg
Precautions & Notes
• Experimental behaviour of PNC-27 is influenced by membrane composition, peptide concentration, and model system
• Peptide is membrane-active in cell-based models and should be handled with care
• Not intended to infer clinical safety or therapeutic use
• Appropriate controls are essential in cytotoxicity studies
• Intended strictly for laboratory research use; not for human or veterinary application
References
Vogelstein B., Lane D., Levine A.J. Surfing the p53 network. Nature, 2000.
https://pubmed.ncbi.nlm.nih.gov/11099028/
Keywords: PNC-27, p53 Peptide, Research Peptide, HDM-2 Binding Peptide, Synthetic Research Peptide
