PE-22-28 is a synthetic seven-residue peptide corresponding to residues 22-28 of the propeptide (PE) released during the maturation of sortilin, a neuronal sorting receptor. It is a shortened form of the 17-residue peptide spadin (PE 12-28) and retains its C-terminal seven residues.
In electrophysiological and cellular research systems, PE-22-28 has been investigated as an inhibitor of the TREK-1 (K2P2.1) two-pore-domain potassium channel, with reported selectivity over the related K2P channels TREK-2, TRAAK, TRESK and TASK-1. Experimental observations depend on model system, channel expression, concentration and exposure duration, and are used to explore channel mechanisms rather than defined physiological outcomes.
Applications in Research
- Inhibition of TREK-1 (K2P2.1) potassium channel currents in electrophysiology assays
- Selectivity profiling across two-pore-domain (K2P) potassium channels
- Comparative studies with spadin and other sortilin propeptide fragments
- Structure-activity relationship and peptide stability studies
Specifications Summary
Purity: ≥ 99%
Appearance: White to off-white lyophilised powder
Peptide Type: Synthetic sortilin propeptide fragment (PE 22-28)
Molecular Weight: ~773.89 g/mol
Solubility: Water, buffered aqueous solutions
Storage: –20 °C, desiccated, protected from light
Pack Size: 10 mg
Precautions & Notes
- Experimental behaviour of PE-22-28 is influenced by channel expression and assay conditions
- Shortened fragments may show activity and selectivity profiles distinct from the parent peptide spadin
- Buffer composition, pH, and ionic strength may affect peptide stability
- Appropriate experimental controls are recommended
- Intended strictly for laboratory research use; not for human or veterinary application
Keywords: PE-22-28, PE 22-28, Spadin-Derived Peptide, Sortilin Propeptide Fragment, TREK-1, K2P Channel, Synthetic Peptide
